DNA Coursework Example | Topics and Well Written Essays - 750 words

DNA - Coursework Example The enzyme, pyruvate dehydrogenase kinase in humans, has two domains ïÆ'   HATPase_c (Histidine kinase) and BCDHK_Adom3 (Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase). These domains are responsible for the functionality of the protein. The HATPase_c is an ATP binding domain. The enzyme inactivates pyruvate dehydrogenase using ATP. The HATPase_c domain is responsible for the enzyme’s kinase activity. The secondary structure of the pyruvate dehydrogenase kinase protein comprises of two sheets, two beta hairpins, two beta bulges, seven strands, fifteen helices, twenty-eight helix-helix interactions, twenty beta turns and two gamma turns. It also has a potassium ion ligand. The total alignment score for the three sequences is 99.0 for human and chimpanzee, 97.0 for human and dog, and 97.0 for chimpanzee and dog. Most of the amino acids are conserved in all the sequences, except for a few minor variations. The highest score for human and chimpanzee shows a high protein sequence similarity between the two. The entire stretch of the sequences with conserved amino acid clusters are highlighted below: Now that you have familiarized yourself with these sites, I would like you to make a small addition of your own initiative to the report by using any of the features described above or any other tool that you may have discovered. Using the sequence alignment of the pyruvate dehydrogenase kinase enzyme of human, chimpanzee and dog, created using the CLUSTALW program, a phylogram guide tree was created. This tree shows the phylogeny of the three

Illustrate how Shakespeare's Macbeth and John Clare's poetry use Essay

Illustrate how Shakespeare's Macbeth and John Clare's poetry use animals to present a message about human affairs such as politi - Essay Example It encompasses all religions, poetries, arts, histories, dramas, fictions and non-fictions. It enhances and reshapes the readers’ perception of life by providing them a wider spectrum through imaginary or factual narrations. It represents man’s relationship to man using images and symbols. As C. S. Lewis debates that â€Å"Literature adds to reality, it does not simply describe it. It enriches the necessary competencies that daily life requires and provides; and in this respect, it irrigates the deserts that our lives have already become"1. Thus, it is not a mere picture of reality rather it is a process of value addition in it; and represents prevailing cultures and norms of a particular society pointing out its various aspects. Literature can be regarded as a wise teacher. It presents examples, illustrations, and incidents in front of the readers to correlate their own lives and draw intellectual conclusions from them. Symbols and images are the most important tools of literature. Image represents reality whereas symbols stand for comparable aspects. The writers use them to create sharp and vivid images in the minds of the readers so that they may see their own worth in comparison to the characters and factors presented. Other than creating sharp fantasies, images serve to offer a deep penetration into the emotions and feelings of the characters in a particular situation. Thus, whenever a character in Ibsen’s plays feel emotional turmoil, he goes straight to the stove or fire. Fielding plays with the images of clothing and nakedness in ‘Joseph Andrews’ to use them as the symbols of human intentions,2 and status; Shakespeare uses them to explain seven stages of human life3 and Tennyson uses them to present facts in disguise. Animals have been a constant, continuous and effective source of symbols and images in English literature. Writers have used animals to represent and symbolise certain features of human nature. For exampl e, Shakespeare refers to snail to explain the pace of a school going child4; Jonathan Swift offered horse-like yahoos5; Alfred Tennyson has used the image of an eagle in his poem ‘The Eagle’ to explain the vigilance and crookedness with which authoritative ruler takes care of his estate6; Wordsworth has referred to Nightingale and cuckoo bird in ‘Solitary Reaper’ to explain the sweetness and thrill of maiden’s song and voice; Sylvia Plath has used bees7; Adrienne Rich referred to Tigers8, etc. For ages, this sort of imagery had been taken as aesthetics of writers. It is only now that cultural criticism is made upon this particular feature to highlight its social, political and religious aspects. This innovative field of critical study is called, ‘Ecocriticism’. Ecocriticism Ecocriticism challenges the study of literature’s relationship to the world. It is a key to the new awareness of life sciences. The main argument in natural sc iences states that the natural environment is an exclusive contributor to the human life and social values. Cultural change can be induced by the adaptation to the environment. It

Financial Statements Essay Example | Topics and Well Written Essays - 1500 words

Financial Statements - Essay Example This project aims at studying and analyzing the annual report of Home Depot as submitted to the United States SEC in the year 2008. The basic financial statements including the income statement, the balance sheet and the cash flow statements of the company are studied and mapped against the managerial decision making processes of the company in the specific year under study. The consolidated statement of earnings of Home Depot indicates that the company has been extremely proficient in generating revenues in 2008. The total revenue in 2008 was USD 77349 million. The operating expenses of the company were USD 18755 million. This indicates that the company was much efficient in generating high revenues while being able to maintain much lower operating expenses. The net earnings of Home Depot in 2008 were USD 4395 which is favorable when mapped against the industry requirements. In overall, as per the consolidated statement of earnings of Home Depot, the company was performing at a standard level in the year 2008 (Home Depot Inc., 2008, p. 4). The consolidated statement of earnings or the income statement of a company summarizes the revenues that a company has earned during the period of reporting through the sale of its products and services. Also, it includes the expenses that a company has made to produce the revenues during the same period. These expenses may include the selling expenses, overheads, general expenses and depreciation of the assets. The comparison of the revenues and the expenses of a company show the net operating profit of a company. After the deduction of various statutory deductions like taxes and interest expenses, the consolidated statement of earnings of a business represents the net earnings of the company over a specific period of time. The key business decisions like how the return on investment for the company can be improved are

Estimation of the value of gravitational acceleration g based on Essay

Estimation of the value of gravitational acceleration g based on measurements from a simple pendulum - Essay Example Although the results obtained deviated slightly from the documented values, various sources of errors were discussed to account for the error noted. It was concluded that prior to accurate measurement of the quantities involved and reduction of reaction time during measurement, a more accurate value for gravitational acceleration can be evaluated Displacement of a pendulum from its equilibrium position results in a restoring force that is due to gravitational pull that maintains it in a swinging mode. The combination of force of gravity and the mass of the pendulum causes it to oscillate constantly about the equilibrium position (Homer & Bowen, 2014). The particular time required to make one complete oscillation is known as the period. Which can also be determined using equation (1) below. Equation 2 above implies that plotting a graph of the square of periodic time T against the length l of the pendulum is a straight line whose gradient is equal to. Using the gradient from the chart, the gravitational acceleration g can be evaluated. The measurement of error in physical quantities involved is important in determining the accuracy of the results obtained. The error is usually taken as the standard deviation of the measurements. Therefore the error in measurement of length can be determined by equation 3 below Pendulums find many applications in the world including the fact that their regular motion are used to regulate pendulum clocks (Homer & Bowen, 2014). Other applications are typical in seismometers, gravimeters, and accelerometers. As part of the hypothesis, the experiment seeks to determine the gravitational acceleration based on hypothesis that there is a relationship between the periodic time and length of the pendulum in determining the gravitational acceleration. In this research it is assumed that the amplitude of displacement for each trial is the same. The classic setup, for studying

Critical Analysis of the Departments Essay Example | Topics and Well Written Essays - 3000 words

Critical Analysis of the Departments - Essay Example It is a general and accepted notion in financial market that propriety trading is much riskier than non-propriety trading as it results in more volatile trading. Financial analyst believes that firms and investment banks usually leave the financial market in ambiguity when it comes to their quantum of propriety trading and non-propriety trading. TPG believes that it has competitive advantage over other players in the market that is way it has its major investment in propriety trading. Certain percentage of revenue, but comparatively lower, is generated from non-propriety trading which is also referred to as the flow trading. In financial terms, the flow trading is conducted by the firm on behalf of the client funds and the firm’s revenue is the commission earned on this trading. The company has been focusing on its flow trading business as well as it is likely to generate more client information which thus supports propriety trading eventually. The trading department of TPG wo rks in close collaboration with Quantitative Analysis and Sales department which provides the relevant logistic support to the trading department. ... In addition to that, the department is also actively involved in the pricing of derivatives and hedging. This function involves an intricate software development and thus the expertise of the IT department is always required to be at the disposal of the Quantitative Analytics department. The derivative pricing involves advanced numerical techniques and stochastic calculus. The department is also actively involved in risk management which involves both systematic and non-systematic risk. The process usually involves a great deal of time series analysis and back testing. Last but not the least; the department also evaluates the credit analysis. Credit analysis basically involves assessing how much the company is levered which in financial terms would interpret as the debt equity ratio of the company. When the debt to equity ratio of the company exceeds a certain percentage, then the department proactively informs the higher management of the company about the situation and alarming the m to reduce the leverage of the company. Most importantly, the department works for the development of the trading strategy of the firm. Sales The sales department is another crucial department when it comes to the business strategy of the company. The sales department is responsible for approaching the client and maintaining their information. This department acts as the back bone of the organization and is responsible for setting up the web-site through which the trading with the corporate and non-corporate clients is conducted. This department will require a considerable number of highly skilled and dedicated staff who is able to understand the technical need

Latino Urbanism in Los Angeles Essay Example | Topics and Well Written Essays - 500 words

Latino Urbanism in Los Angeles - Essay Example In this report, research into the Latino community is carried out in all thats considered as common ground by the community (Rojas 44). The research is done on the streets, abandoned train yards, residential home front yards and backyards, designated sacred sites, burial sites, cafà © and shops among other social hubs. The Latino community makes use of all space outdoors, forcing the researcher to base the research on the outdoors. In conducting research on a social platform, James gathered most of the data via personal observation. Since his report is derived from the behavior of the community, observing the community trends is the preferred data gathering technique. Although it is not indicated in the report, James interviewed some of the community members to get a perspective on their mode of living. James illustrates the improvisation, innovation and use the Latino community makes with the few resources they have. He introduces the personalization element adopted by the community in the absence of government

Paper-Based Versus Electronic Medical Record Keeping Essay Example for Free

Paper-Based Versus Electronic Medical Record Keeping Essay For many years, physicians’ offices documented all data in paper-based medical charts. Now, the physician or clinician records the medical data into a computer. Information stored in this manner is known as an electronic-based medical record or EMR. By definition, an EMR is a computerized record of the important health information regarding a patient including the care of that individual and the progress of that patient’s condition (Bonewit-West, Hunt, Applegate, 2009). The use of computers in physicians’ offices is not new. For decades, physicians have used computers and practice management software primarily to schedule appointments and for billing. The government has offered physicians incentives designed to encourage the adoption of electronic medical records to promote medical information accessibility, better patient care, greater efficiency, and financial savings (Hamilton, 2010). In the face of advancing technology, small medical offices must compare the cost, ease of use, and maintenance of electronic medical record systems versus paper-based record keeping. The cost of keeping paper-based and electronic medical records is not just about the actual price tag of the record-keeping systems. The cost of keeping an electronic medical record system (EMR) begins with the initial purchase and implementation of the hardware and EMR software. There are also ongoing maintenance expenses, loss of revenue associated with temporary loss of productivity due to converting paper charts to electronic ones, and the training of the staff (Menachemi Collum, 2011). The way these record systems are stored is very different and can greatly affect the cost as well. EMR records are stored on a server, digitally, in a secure computer database within the office practice (Hamilton, 2010). On the other hand, the cost of keeping a paper-based medical record requires certain supplies. File folders, folder labels, chart dividers, paper, and writing instruments are needed. Shelves are commonly used to hold and organize the charts for ease of accessibility by the staff. A growing medical practice may often require many shelving units that take up valuable office space. Storage boxes are required to store outdated charts or charts no longer in use (Bonewit-West et al., 2009). If there is not enough space in the office, then physicians may often have to pay for off-site storage (Hamilton, 2010).  The process of using a paper-based medical record system is relatively easy. However, there are some factors to consider. To use a paper chart, the medical staff must locate and retrieve it, make sure the appropriate documents accompany the chart, and have it ready for the physician. The physician or the medical staff must allocate enough time to accurately document the chart for each patient. Any chart, whether it is paper or electronic, needs to be comprehensible, so clear writing is imperative when recording using a paper chart (Bonewit-West et al., 2009). Meanwhile, using an EMR system requires the use of a computer. This can be a desktop model, laptop, or a tablet type device. The patient records are kept digitally within the EMR system and are accessed via the computer. This type of record-keeping system does not require the addition of paper documents. Al l paper documents are scanned into the EMR system or electronically obtained from other pertinent sources. Once paper documents are scanned into the EMR system, they become part of the patient’s permanent record and are no longer needed. This process requires EMR training of the medical staff, which is normally performed by the vendor supplying the EMR software. The physician and the medical staff must learn how to operate the new system and acclimate to the new paperless charting method. Learning an EMR program and using it with ease can take several months or more (Bonewit-West et al., 2009). The ease of use with both of these systems differs in the fact that paper-based records need to be filed properly in order to locate them when needed. Filing can be very time-consuming and paper-based records can be easily lost or destroyed. Even though electronic records are stored digitally on a server within the medical office, the medical staff will still need to enter the patient data into the EMR system. Electronic records need to be backed up daily because they can be lost due to fail ure of the hardware (Hamilton, 2010). Regular maintenance is required for both paper-based and electronic record keeping. The maintenance differs greatly between the systems and is ongoing regardless of which system is being used in the medical office. The routine maintenance of an electronic medical record system requires hiring network professionals to monitor and maintain the network. Some examples of maintenance tasks may include performing data backup once every twenty-four hours, storing a database backup offsite, and  archiving backup media once every month. There is also maintenance on the hardware and software. Hardware must be replaced and software will have to be upgraded regularly. A product specialist may need to run utilities for different applications within the EMR system. There will be ongoing training for all users of the electronic medical records system (Menachemi Collum, 2011). In contrast to electronic medical records, maintenance of paper charts require that they are examined periodically to make sure the chart remains in good condition since these charts will become worn over time. The charting of each patient should be complete, legible, and performed in a timely fashion. Paper charts that are outdated, that are deemed inactive or charts of patients who expired will have to be placed in boxes and put into storage (Hamilton, 2010). There are vast differences between paper-based and electronic medical record-keeping systems. One system is entirely manual while the other requires manual data entry combined with computerization. For decades, physicians and staff of medical practices have used only the manual or paper-based method of keeping medical records. Change can be costly and frustrating, but with the advancement of technology, coupled with the government requiring the use of EMR, small medical offices must explore the cost, ease of use, and maintenance involved in making this important change in the way of keeping medical records. References Bonewit-West, K., Hunt, S. A., Applegate, E. J. (2009). The medical record. In Todays Medical Assistant: Clinical Administrative Procedures. St. Louis, Mo: Saunders/Elsevier. Hamilton, B. (2010). Electronic health records (2nd ed.). New York, NY: McGraw-Hill Higher Education. Menachemi, N., Collum, T. (2011). Benefits and drawbacks of EHRs. Risk Management and Healthcare Policy, 4, 47-55. Retrieved from doi:10.2147/RMHP.S12985.